The symposium aims to address the challenges and future directions in the risk assessment of genotoxic substances. It will bring together experts from different disciplines either from academia, industry or regulatory authorities worldwide to present and discuss their activities.

So far, genotoxicity data are mainly interpreted in a qualitative way, which typically results in a binary classification of chemical entities. However, there is a long-lasting and controversial discussion about the need for a paradigm shift in this regard. With lectures, workshops and a concluding panel the symposium will build a platform to discuss the current opportunities, challenges and perspectives for a more quantitative approach to genotoxicity assessment.

The symposium aims to foster collaboration and knowledge exchange, leading to improved risk assessment strategies for genotoxic substances.

It is intended for experts with experience in genotoxicity assessment and will take place as a face-to-face meeting in Berlin.

Venue:
German Federal Institute for Risk Assessment (BfR)
lecture theater
Diedersdorfer Weg 1
12277 Berlin

Directions
bfr-akademie.de/english/locations/marienfelde.html

Destination stop (www.bahn.com/en, www.bvg.de/en):
“Nahmitzer Damm/Marienfelder Allee (Berlin)”

Programme

Diane Benford, Scientific Committee of the European Food Safety Authority (EFSA), Italy
"Classical approaches" in genotoxicity assessment

Frans Verstraete, European Commission, Belgium
Genotoxic compounds in EU food safety policy

Paschalina Papadaki, European Chemicals Agency (ECHA), Finland
ECHA’s view

Alexis Nathanail, Juan Parra Morte, EFSA, Italy
EFSA’s view

Roland Frötschl, Federal Institute for Drugs and Medical Devices (BfArM), Bonn
BfArM’s view

Laura Markley, U.S. Food and Drug Administration (US FDA), USA
US FDA’s view

Workshop 1 Risk assessment of genotoxic compounds in the presence of data from carcinogenicity studies
presentation with the results of workshop 1

Workshop 2 Quantitative assessment of genotoxic compounds in the absence of data from carcinogenicity studies
presentation with the results of workshop 2

Workshop 3 New approaches for the characterisation of genotoxic effects based on in vitro and in silico data
presentation with the results of workshop 3

Workshop 4 New approaches for the quantitative characterisation of genotoxic effects based on animal and human data
presentation with the results of workshop 4