The “10^th Berlin Workshop on Developmental Toxicology” is aimed to bring together international experts from authorities, research institutions, universities and industry to discuss the final update of the DevTox database, to consider specific aspects in regulatory risk assessment of developmental neurotoxicity and to debate alternative strategies in testing developmental effects in the future with the main goal to improve harmonisation in the worldwide assessment of developmental findings and laboratory investigations.
The topics are grouped in three different main panels. Results of the discussions will be published by the German Federal Institute for Risk Assessment (BfR):

• The DevTox-Project
• Risk Assessment – Developmental Neurotoxicity
• Future Methodology in DevTox

The 10^th Berlin Workshop (BW) is a continuation of a series of Berlin Workshops. At the last BW 2018, the need for a harmonised terminology for classification
of anomalies in laboratory animals in developmental toxicity studies aiming for human health risk assessment was emphasised and the DevTox database was
identified as an extremely valuable tool. It was also agreed that still one of the biggest challenges for testing developmental toxicity in the 21^st century is the development of animal-free test strategies and alternatives to animal testing that could provide information relevant for humans in a rapid, efficient, and mechanistically informative manner.
Presentations and main results of the 10^th Workshop will be published on the BfR Website. A report of the workshop will be published in a peer reviewed journal.

Programme

Live stream recordings

Presentation slides from 19.02.2020

Roland Solecki, BfR
Key note lecture: 10th Berlin-Workshop on Developmental Toxicology

Konstanze Grote and Ibrahim Chahoud, Charité Berlin
Key note lecture: where we were and where we are now

Rupert Kellner, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover
Key note lecture: 25 years DevTox Workshops: historic background, scientific and technical improvements

Jochen Buschmann, Idependent Consultant, Hannover
Follow up activities of the Berlin Workshop with the JTS and ETS

Weihua Li, Shanghai Institute of Planned Parenthood Research, Shanghai, China
New Pictures in the DevTox Database

Michio Fujiwara, Astellas Pharma Inc., Tokyo, Japan
Japanese proposal for update of definitions and re-categorization of grey zone anomalies

Alberto Mantovani, Istituto Superiore di Sanità, Rome, Italy
View of a developmental toxicologist from the EU

Francisco Paumgartten, Fiocruz, Rio de Janeiro, Brazil
Berlin Workshop view on a new survey for recategorisation of grey zone anomalies

Magda Sachana, Organisation for Economic Cooperation and Development, Paris, France
OECD framework for a DNT testing Battery and Case studies

Marcel Leist, Universität Konstanz
Linking test systems to the prediction of DNT

Anna Bal-Price, European Commission
Adverse Outcome Pathways (AOPs)-driven evaluation of developmental neurotoxicity (DNT) induced by mixture of environmental chemicals

Presentation slides from 20.02.2020

Makiko Kuwagata, National Institute of Health Sciences, Kawasaki, Japan
Research on the mechanism of thoracolumbar supernumerary rib by use of computed tomography (CT)